Open Access<p>Overexpression of RNF126 Promotes the Development of Colorectal Cancer via Enhancing p53 Ubiquitination and Degradation</p>
Author(s) -
Shiyang Wang,
Tianlong Wang,
Li Wang,
Liansheng Zhong,
Kai Li
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s271855
Subject(s) - mg132 , gene silencing , ubiquitin ligase , ubiquitin , cancer research , downregulation and upregulation , colorectal cancer , transfection , chemistry , proteasome inhibitor , proteasome , cell growth , cancer , microbiology and biotechnology , biology , cell culture , gene , biochemistry , genetics
RING finger protein 126 (RNF126), as a novel E3 ubiquitin ligase, plays an oncogenic role in several solid cancers. But its potential role in colorectal cancer (CRC) that harbored 50% mutant p53, to our knowledge, is rarely reported.