Open Access<p>USP8 Inhibitor Suppresses HER-2 Positive Gastric Cancer Cell Proliferation and Metastasis via the PI3K/AKT Signaling Pathway</p>
Author(s) -
Jianfang Sun,
DanDan Shen,
YiChao Zheng,
Hongmei Ren,
HongMin Liu,
Xiaoping Chen,
Yongshun Gao
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s271496
Subject(s) - cancer research , cell growth , ubiquitin , pi3k/akt/mtor pathway , cancer , protein kinase b , biology , metastasis , signal transduction , microbiology and biotechnology , medicine , gene , biochemistry
Referring to global cancer statistics, the incidence of gastric cancer (GC) was ranked sixth; however, detailed mechanisms underlying its development were not thoroughly investigated. Previous studies have reported that inhibition of ubiquitin-specific peptidase 8 (USP8) induced degradation of several receptor tyrosine kinases, such as epidermal growth factor receptor (EGFR), embryonic stem cells (ESCs), etc. Nevertheless, the regulation of HER-2 by USP8 and the molecular mechanisms controlling their role in the pathogenesis of GC remain unknown.