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Although programmed death-ligand 1 (PD-L1) expression is widely accepted as a predictive and prognostic biomarker in immunotherapy, its implications in lung cancer patients with driving mutations are still unclear. The objective of this study is to determine the association between PD-L1 expression and treatment outcome in epidermal growth factor receptor ( EGFR )-mutated lung cancer treated with tyrosine kinase inhibitors (TKIs).

oncotargets and therapy

&lt;p&gt;High PD-L1 Expression is Associated with Unfavorable Clinical Outcome in &lt;em&gt;EGFR&lt;/em&gt;-Mutated Lung Adenocarcinomas Treated with Targeted Therapy&lt;/p&gt;