Open Access<p>Suppressing UVRAG Induces Radiosensitivity by Triggering Lysosomal Membrane Permeabilization in Hypopharyngeal Squamous Cell Carcinoma</p>
Author(s) -
Jianwen Wang,
Xuehai Wang,
Kai Liu,
Leyi Gu,
Lei Yu,
Han Liang,
Zhaojin Meng
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s270433
Subject(s) - autophagy , radioresistance , cancer research , radiosensitivity , dna damage , cell , chemistry , downregulation and upregulation , cell culture , microbiology and biotechnology , biology , radiation therapy , apoptosis , medicine , gene , dna , biochemistry , genetics
Radiotherapy is one of the most important methods in the treatment of patients with hypopharyngeal squamous cell carcinoma (HSCC). However, radioresistance will be developed after repeated irradiation. Among many key factors contributing to radioresistance, enhanced autophagy is recognized as one of the most important. The ultraviolent irradiation resistance-associated gene (UVRAG) is reported to be a crucial gene involved in the process of autophagy. Here, we test whether UVRAG has effect on the radioresistance of HSCC.