Open AccessNovel Small Molecular Compound AE-848 Potently Induces Human Multiple Myeloma Cell Apoptosis by Modulating the NF-κB and PI3K/Akt/mTOR Signaling Pathways
Author(s) -
Yiyao Xu,
Xiaoli Feng,
Qian Zhou,
Jiangqi Wen,
Yibo Dai,
Yang Jiang,
Xiaoli Liu,
Shuo Li,
Yongjing Wang,
Fang Wang,
AiHsien Li,
Chengyun Zheng
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s270090
Subject(s) - pi3k/akt/mtor pathway , apoptosis , viability assay , chemistry , blot , protein kinase b , poly adp ribose polymerase , microbiology and biotechnology , mtt assay , cell growth , cancer research , biology , biochemistry , polymerase , enzyme , gene
We aimed to investigate the anti-multiple myeloma (MM) activity of the new small molecular compound AE-848 (5-bromo-2-hydroxyisophthalaldehyde bis[(1-methyl-1H-benzimidazol-2-yl)hydrazone]) and its underlying anti-MM mechanism.