Open Access<p>RNF128 Promotes Malignant Behaviors via EGFR/MEK/ERK Pathway in Hepatocellular Carcinoma</p>
Author(s) -
Xuesong Bai,
Chi Zhang,
Rui Peng,
GuoQing Jiang,
Shengjie Jin,
Qian Wang,
Ai–Wu Ke,
DouSheng Bai
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s269606
Subject(s) - hepatocellular carcinoma , mapk/erk pathway , medicine , cancer research , mek inhibitor , oncology , kinase , biology , genetics
The ubiquitin-proteasome system participates in the pathogenesis and progression of hepatocellular carcinoma (HCC). As an E3 ubiquitin ligase, RNF128 has been proved vital in carcinogenesis, whereas, little is known about the oncogenic mechanisms of RNF128 in HCC.