Open AccessUltrasound-Targeted Microbubble Destruction-Mediated Downregulation of EZH2 Inhibits Stemness and Epithelial-Mesenchymal Transition of Liver Cancer Stem Cells
Author(s) -
Jie Wu,
Lulu Sun,
Tingting Liu,
Gang Dong
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s269589
Subject(s) - epithelial–mesenchymal transition , cancer research , cancer stem cell , vimentin , pi3k/akt/mtor pathway , transfection , liver cancer , downregulation and upregulation , viability assay , stem cell , protein kinase b , cancer , chemistry , medicine , pathology , biology , cell , cell culture , signal transduction , immunohistochemistry , metastasis , microbiology and biotechnology , hepatocellular carcinoma , biochemistry , genetics , gene
Cancer cells could show the characteristics of cancer stem cells (CSCs) through epithelial-mesenchymal transition (EMT). EZH2 was associated with EMT. Ultrasound-targeted microbubble destruction (UTMD) could enhance gene transfection efficiency. Here, we explored the effect of UTMD-mediated shEZH2 on liver CSCs.