Open Access<p><em>MST4</em> Regulates Epithelial–Mesenchymal Transition of Choriocarcinoma by Mediating TGF-β1 Expression</p>
Author(s) -
Hanxi Yu,
Weichen Zhang,
Peilin Han,
Beng Yang,
Xiaode Feng,
Ping Zhou,
XiaoXu Zhu,
Bingqian Zhou,
Wei Wei Chen,
Jiang Qian,
Jun Yu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s269168
Subject(s) - choriocarcinoma , cancer research , biology , microbiology and biotechnology , genetics
Mammalian Ste20-like kinase 4 ( MST4 ), also known as serine/threonine kinase 26 ( STK26 ), promotes development of several cancers and is found to be highly expressed in the placenta. However, in choriocarcinoma that originated from the placenta, the expression of MST4 was undetermined and its mechanism was unknown. In this study, the expression of MST4 in choriocarcinoma as well as the underlying mechanism was explored.