Open Access<p>Metformin Combined with 4SC-202 Inhibited the Migration and Invasion of OSCC via STAT3/TWIST1</p>
Author(s) -
Yuan He,
Fanfang Zeng,
Lihong He,
Chi Zhang,
Fan Ping,
Miao Deng,
Suyang Liu,
Yanting Wang,
Bin Cheng,
Juan Xia
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s268851
Subject(s) - metformin , stat3 , cancer research , medicine , cell migration , apoptosis , gentamicin protection assay , western blot , in vivo , in vitro , metastasis , biology , cancer , gene , biochemistry , microbiology and biotechnology , insulin
Oral squamous cell carcinoma (OSCC), the most common epithelial malignant neoplasm in the head and neck, characterizes with local infiltration and metastasis of lymph nodes. The five-year survival rate of OSCC remains low despite the advances in clinical methods. Thus, it is necessary to develop a new effective therapeutic scheme for OSCC. Our previous results showed that metformin and 4SC-202 synergistically promoted the intrinsic apoptosis of OSCC in vitro and in vivo, but the effects on invasion and migration remained unclear.