Open Access<p>α-MSH-PE38KDEL Kills Melanoma Cells via Modulating Erk1/2/MITF/TYR Signaling in an MC1R-Dependent Manner</p>
Author(s) -
Xilin Li,
Hong Li,
Xianling Cong,
Da Huo,
Lele Cong,
Guangzhi Wu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s268554
Subject(s) - microphthalmia associated transcription factor , melanoma , sox10 , medicine , cancer research , signal transduction , endocrinology , biology , microbiology and biotechnology , genetics , transcription factor , gene , embryo , neural crest
The immunotoxin α-MSH-PE38KDEL consisting of α-MSH and PE38KDEL showed high cytotoxicity on MSH receptor-positive melanoma cells, suggesting that α-MSH-PE38KDEL might be a potent drug for the treatment of melanoma. Herein, we explored whether the Erk1/2/MITF/TYR signaling, a verified target of α-MSH/MC1R, was involved in α-MSH-PE38KDEL-mediated cytotoxicity.