Open Access<p>miR-135b-5p Suppresses Androgen Receptor-Enhanced Hepatocellular Carcinoma Cell Proliferation via Regulating the HIF-2α/c-Myc/P27 Signals in vitro</p>
Author(s) -
Shixiang Bao,
Chunhua Wang,
Shuai Jin,
Kongwang Hu,
Jing-Tao Lü
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s268214
Subject(s) - chromatin immunoprecipitation , androgen receptor , cancer research , cell growth , downregulation and upregulation , microrna , hepatocellular carcinoma , chemistry , biology , medicine , cancer , gene expression , promoter , prostate cancer , gene , biochemistry
Hepatocellular carcinoma (HCC) accounts for more than 90% of liver cancers and is ranked as the fifth most common malignancy. Androgen receptor (AR) may promote the progression of HCC at an early stage of the disease. However, this study identified miR-135b-5p as an AR upstream regulator can suppress AR protein expression and inhibit HCC proliferation, consistent with the idea that AR expression is negatively correlated with HCC progression.