Open AccessPolysaccharides Derived from Saposhnikovia divaricata May Suppress Breast Cancer Through Activating Macrophages
Author(s) -
Jingxian Ding,
Ying Guo,
Xiaoliu Jiang,
Qingge Li,
Kai Li,
Min Liu,
Wenbing Fu,
Yimei Cao
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s267984
Subject(s) - u937 cell , polysaccharide , cancer research , chemistry , cell growth , in vitro , growth inhibition , cell culture , pharmacology , medicine , biochemistry , biology , genetics
Saposhnikovia divaricata (SD) has been used in traditional Chinese medicine to treat pain, inflammation, and arthritis. Recently, it has been reported that SD extract may inhibit tumor growth, but the mechanism involved is elusive. The aim of this study was to investigate the anti-tumor activity of polysaccharides derived from SD in breast cancer and the underlying mechanisms.