Open AccessHighly Sensitive Droplet Digital PCR Method for Detection of de novo EGFR T790M Mutation in Patients with Non-Small Cell Lung Cancer
Author(s) -
Xun Wang,
Xiao Li,
Hui Guo,
Lingxiang Zhu,
Zhiyong Peng,
Jun Wang,
Fan Yang,
Yong Guo
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s267677
Subject(s) - t790m , mutation , digital polymerase chain reaction , lung cancer , microbiology and biotechnology , cancer research , medicine , biology , pathology , polymerase chain reaction , genetics , gene , kras
The aim of this study was to investigate the allelic relation between de novo T790M and concomitant sensitizing EGFR mutations in EGFR-TKIs naïve NSCLCs and to explore whether the formalin-fixed and paraffin-embedded (FFPE) materials affect the detection of de novo EGFR T790M mutation.