Open Access<p>ITPKA1 Promotes Growth, Migration and Invasion of Renal Cell Carcinoma via Activation of mTOR Signaling Pathway</p>
Author(s) -
Xiang Zhu,
An Xu,
Yang Zhang,
Nan Huo,
Rui Cong,
Luyuan Ma,
Zhong Chu,
Zhi Tang,
Xiaofeng Kang,
Shaozhong Xian,
Xiaojie Xu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s266095
Subject(s) - mtorc1 , pi3k/akt/mtor pathway , cancer research , cell growth , biology , carcinogenesis , signal transduction , renal cell carcinoma , cancer , medicine , microbiology and biotechnology , pathology , genetics
Renal cell cancer (RCC) is one of the most lethal malignancies of the kidney in adults. mTOR (mammalian target of rapamycin) signaling pathway plays a pivotal role in RCC tumorigenesis and progression and inhibitors targeting the mTOR pathway have been widely used in advanced RCC treatment. Therefore, it is of great significance to explore the potential regulators of the mTOR pathway as RCC therapeutic targets.