Open AccessExpression and Prognostic Role of PLOD1 in Malignant Glioma
Author(s) -
Hao Wang,
Weijian Luo,
Lei Dai
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s265866
Subject(s) - glioma , idh1 , immunohistochemistry , cancer research , medicine , kegg , extracellular matrix , pathology , oncology , biology , gene expression , gene , transcriptome , mutation , biochemistry , microbiology and biotechnology
Malignant glioma is rarely curable, and factors that inuence the prognosis of glioma patients are not fully understood. Lysyl hydroxylases such as PLOD1 promote the cross-linking in extracellular matrix (ECM) molecules, which contribute to ECM structural stability and maturation. However, the expression and prognostic role of PLOD1 in malignant glioma remained to be determined.