Open Access<p>MiRNA505/NET1 Axis Acts as a CD8<sup>+</sup> T-TIL Regulator in Non-Small Cell Lung Cancer</p>
Author(s) -
Pengyuan Zhu,
Zhenchuan Liu,
Haitao Huang,
Chongjun Zhong,
Yilu Zhou
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s265859
Subject(s) - cd8 , cancer research , lung cancer , luciferase , microrna , adenocarcinoma , regulator , immunotherapy , tumor microenvironment , cytotoxic t cell , biology , immunohistochemistry , function (biology) , western blot , immune system , medicine , cancer , immunology , gene , pathology , microbiology and biotechnology , tumor cells , genetics , transfection , in vitro
Lung adenocarcinoma (LUAD), which is the most important and common subtype of non-small cell lung cancer (NSCLC), is highly heterogeneous with a poor prognosis and poses great challenges to health worldwide. MicroRNAs (miRNAs) are regulators of gene expression with recognized roles in physiology and diseases, such as cancers, but little is known about their functional relevance to CD8 + T cell infiltration regulation in the tumor microenvironment (TME) of NSCLC patients, especially LUAD patients.