Open Access<p>Identification of P-Rex1 in the Regulation of Liver Cancer Cell Proliferation and Migration via HGF/c-Met/Akt Pathway</p>
Author(s) -
Wancheng Qiu,
Yanhua Chang,
Jing Liu,
Yang Xu,
Yan Yu,
Jiajia Li,
Liang Qi,
Guangchun Sun
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s265592
Subject(s) - protein kinase b , gene knockdown , rex1 , cancer research , cell growth , guanine nucleotide exchange factor , cell migration , carcinogenesis , biology , signal transduction , microbiology and biotechnology , cancer , cell , embryonic stem cell , apoptosis , biochemistry , genetics , induced pluripotent stem cell , gene
Rho-GTPases and their activators, guanine nucleotide exchange factors (GEFs), are increasingly being recognized as essential mediators of oncogenic signaling. Although it is known that P-Rex1, a member of the Dbl family of GEFs for the Rac small GTPase, contributes to the migration of cancer cells, its exact role in liver cancer and the underlying mechanisms remain unclear.