Open AccessDownregulation of PFTK1 Inhibits Migration and Invasion of Non-Small Cell Lung Cancer
Author(s) -
Mei Jiang,
Qi Chen,
Xiaoting Zhao,
Yuee Teng,
Chenghong Yin,
Wentao Yue
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s265540
Subject(s) - downregulation and upregulation , vimentin , cell migration , cancer research , metastasis , rhoa , gene knockdown , lung cancer , epithelial–mesenchymal transition , western blot , motility , biology , actin cytoskeleton , cell , cancer , pathology , cell culture , medicine , microbiology and biotechnology , immunology , cytoskeleton , signal transduction , immunohistochemistry , gene , biochemistry , genetics
PFTK1, a novel cyclin-dependent kinase, plays pivotal roles in tumorigenesis. Cell motility and invasiveness could be enhanced by PFTK1 in various tumors. However, the function of PFTK1 in NSCLC metastasis remains unclear. In this study, the potential role of PFTK1 in NSCLC metastasis was determined.