Open Access<p>Cervical Cancer: Emerging Immune Landscape and Treatment</p>
Author(s) -
Lina Guo,
Keqin Hua
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s264312
Subject(s) - immune system , cervical cancer , immunotherapy , medicine , immunology , carcinogenesis , cancer , immune checkpoint , human papillomavirus , cancer research
Immune cells are essential for defending the body's balance and have increasingly been implicated in controlling tumor growth. In cervical cancer (CC), the immune landscape is extensively connected with human papillomavirus (HPV) status. Recent insights from studies have revealed that as a result of infection with HPV, immune cell populations such as lymphocytes or monocytes change during carcinogenesis. Immune therapy, in particular checkpoint inhibitors, those targeting PD-1 or PD-L1, has shown promising efficacy. This article reviews the immune landscape and immunotherapy of CC.