Open Access<p><em>KIF5B</em>-<em>EGFR</em> Fusion: A Novel <em>EGFR</em> Mutation in Lung Adenocarcinoma</p>
Author(s) -
Hui Xu,
Chengchen Shao
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s263994
Subject(s) - epidermal growth factor receptor , lung cancer , cancer research , medicine , adenocarcinoma , tyrosine kinase , fusion gene , mutation , cancer , oncology , gene , receptor , biology , genetics
With the rapid development of detection methods, next-generation sequencing (NGS) technology as a new technology, some novel epidermal growth factor receptor (EGFR) gene fusions comprising the EGFR linked to various fusion partners, most commonly RAD51 , are detected in the non-small cell lung cancer (NSCLC). We described a case of an unreported kinesin family member 5B ( KIF5B )- EGFR in NSCLC and the efficacy of EGFR tyrosine kinase inhibitors (TKIs) to this specific fusion. Considering this rare EGFR fusion and remarkable response to EGFR-TKI, we should realize the importance of these rare EGFR fusions, the advances in diagnostic techniques and personalized care for lung cancer patients.