Open Access<p>Prophylactical Low Dose Whole-Liver Irradiation Inhibited Colorectal Liver Metastasis by Regulating Hepatic Niche in Mice</p>
Author(s) -
Lu Wang,
Yan Sun,
Xiaoxiao Luo,
Han Huang,
Han Yin,
Ben Zhao,
Xinyi Chen,
Qianqian Yu,
Hong Qiu,
Xianglin Yuan
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s263858
Subject(s) - timp1 , colorectal cancer , metastasis , mmp1 , hepatic stellate cell , medicine , cancer research , pathology , cancer , biology , gene expression , biochemistry , gene
The liver is the most common target for metastatic colorectal cancer. Changes of the local hepatic niche due to hepatic diseases such as cirrhosis decrease the incidence of colorectal cancer liver metastasis. Hepatic niche heterogeneity could influence the risk of hepatic metastasis.