Open Access<p><em>TAGLN</em> and High-mobility Group AT-Hook 2 (HMGA2) Complex Regulates TGF-β-induced Colorectal Cancer Metastasis</p>
Author(s) -
Huimin Zhou,
Lan Li,
Wen-Rui Xie,
LiHao Wu,
Ying Lin,
Xinxin He
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s263090
Subject(s) - epithelial–mesenchymal transition , cancer research , metastasis , vimentin , mmp2 , gene knockdown , cell migration , transforming growth factor , chemistry , cancer , biology , cell , microbiology and biotechnology , apoptosis , medicine , immunology , immunohistochemistry , biochemistry
Colorectal cancer is one of the three most common cancers worldwide. Altered TGF-β signaling pathway in colorectal cancer is associated with metastasis and poor prognosis. It is also involved in epithelial-to-mesenchymal transition (EMT), which is essential in progression and metastasis. This study aims to investigate the role of transgelin ( TAGLN ) and high-mobility group AT-hook 2 (HMGA2) in the progression of colon cancer.