Open Access<p>Treatment for Liver Tumor Using Combined Transarterial Embolization and Interaarterial Transfecting HIF-1α shRNA in a Rabbit VX2 Model</p>
Author(s) -
Chuangen Guo,
Cheng Wang,
Jingfeng Zhang,
Xiao Chen
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s262434
Subject(s) - small hairpin rna , hepatocellular carcinoma , medicine , vascular endothelial growth factor , transfection , genetic enhancement , liver cancer , cancer research , gastroenterology , pathology , apoptosis , chemistry , vegf receptors , gene , biochemistry , gene knockdown
Hypoxia-inducible factor-1α ( HIF -1α) has been selected as therapeutic gene in gene therapy. The aim of this study was to explore the treatment effect of combined transarterial embolization using microsphere treatment (MD) and intraarterial transfecting HIF-1α shRNA on hepatocellular carcinoma (HCC).