Open Access<p>Downregulation of IRAK1 Prevents the Malignant Behavior of Hepatocellular Carcinoma Cells by Blocking Activation of the MAPKs/NLRP3/IL-1β Pathway</p>
Author(s) -
Wei Wei Chen,
Tao Wei,
Yinghua Chen,
Lan Yang,
Xiaomin Wu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s260793
Subject(s) - downregulation and upregulation , hepatocellular carcinoma , blocking (statistics) , cancer research , kinase , chemistry , microbiology and biotechnology , medicine , biology , gene , biochemistry , computer science , computer network
Interleukin-1 receptor-associated kinase 1 (IRAK1) was shown to contribute to a variety of cancer-related processes. However, the function of IRAK1 in hepatocellular carcinoma (HCC) pathogenesis has not been investigated in detail.