Open Access<p>Simultaneous Treatment with Soluble Forms of GAS1 and PTEN Reduces Invasiveness and Induces Death of Pancreatic Cancer Cells</p>
Author(s) -
Lizbeth Daniel-García,
Paula Vergara,
Araceli Navarrete,
Rosa O. González,
José Segovia
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s260671
Subject(s) - pten , protein kinase b , cancer research , pancreatic cancer , in vivo , perineural invasion , apoptosis , cancer , cell growth , intracellular , cell , medicine , mapk/erk pathway , pi3k/akt/mtor pathway , biology , chemistry , signal transduction , microbiology and biotechnology , biochemistry
Pancreatic carcinoma cells exhibit a pronounced tendency to invade along and through intra and extrapancreatic nerves, even during the early stages of the disease, a phenomenon called perineural invasion (PNI). Thus, we sought to determine the effects of the simultaneous expression of soluble forms of GAS1 and PTEN (tGAS1 and PTEN-L) inhibiting tumor growth and invasiveness.