Open Access<p>Combination of CpG Oligodeoxynucleotide and Anti-4-1BB Antibody in the Treatment of Multiple Hepatocellular Carcinoma in Mice</p>
Author(s) -
Shizhao Ma,
Xinying Yang,
Hongyu Zhou,
Chaoqun Zhang,
Jiwen Kang,
Dongdong Sun
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s260353
Subject(s) - spleen , medicine , ctl* , antibody , hepatocellular carcinoma , cd8 , cpg oligodeoxynucleotide , immune system , cpg site , immunology , immunotherapy , biology , biochemistry , gene expression , dna methylation , gene
To investigate the effect of topical application of CpG oligodeoxynucleotide (CpG-ODN) combined with anti-4-1BB antibodies on mouse HCC multiple tumor-bearing models and the degree of improvement of anti-tumor immune response in mice.