Open Access<p>Aloperine Exerts Antitumor Effects on Bladder Cancer in vitro</p>
Author(s) -
Lijun Zhang,
Jun Liang,
Xiaohua Liu,
Jianhua Wu,
Daqing Tan,
Wei Hu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s260215
Subject(s) - urothelium , apoptosis , urothelial cell , cancer research , bladder cancer , cancer , medicine , western blot , cancer cell , mtt assay , cell growth , cell culture , pathology , urinary bladder , chemistry , biology , biochemistry , genetics , gene
Human bladder cancer is the most common malignant tumor of the urinary system and one of the 10 most common tumors of the whole body. Although most patients with bladder cancer exhibit a good prognosis with standard treatment, effective therapies for patients with a recurrent or advanced bladder cancer are unavailable. Therefore, highly effective drugs to treat such patients need to be developed. Aloperine (ALO), a natural compound isolated from Sophora alopecuroides , has antitumor properties. However, the role of ALO in human bladder cancer remains unclear.