Open Access<p>Inactivation of Pancreatic Stellate Cells by Exendin-4 Inhibits the Migration and Invasion of Pancreatic Cancer Cells</p>
Author(s) -
Ming Yan,
Manru Shen,
Liang Xu,
Jingjing Huang,
Guijun He,
Min An,
Xiaocui Li,
Zhihua Gao,
Xin Meng
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s259853
Subject(s) - pancreatic cancer , hepatic stellate cell , metastasis , cancer research , in vivo , cell migration , cancer cell , cxcr4 , cell growth , receptor , in vitro , medicine , cancer , chemistry , biology , chemokine , biochemistry , microbiology and biotechnology
Pancreatic stellate cells (PSCs) are precursor cells of cancer-associated fibroblasts that promote tumor proliferation, invasion, and metastasis. The glucagon-like peptide-1 receptor agonist exendin-4 has been reported to exhibit anticancer effects against several tumor cells; however, the function and mechanism underlying the effects of exendin-4 on pancreatic cancer cells remain unclear.