Open Access<p>Resveratrol Suppresses Tumor Progression via Inhibiting STAT3/HIF-1α/VEGF Pathway in an Orthotopic Rat Model of Non-Small-Cell Lung Cancer (NSCLC)</p>
Author(s) -
Huixia Wang,
Ruzhen Jia,
Tianle Lv,
Mei Wang,
Shiwei He,
Xia Zhang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s259016
Subject(s) - medicine , lung cancer , stat3 , resveratrol , apoptosis , western blot , lung , angiogenesis , cancer research , oncology , pharmacology , biology , biochemistry , gene
The STAT3/HIF-1α/VEGF pathway is associated with the development and progress of various tumors including NSCLC. The aim of the present study was to investigate whether resveratrol (RES) could suppress NSCLC progression via inhibiting the expressions of STAT3, HIF-1α, and VEGF in a nude rat model.