Open Access<p>LHX6 Affects Erlotinib Resistance and Migration of <em>EGFR</em>-Mutant Non-Small-Cell Lung Cancer HCC827 Cells Through Suppressing Wnt/β-Catenin Signaling</p>
Author(s) -
Qiang Wang,
Jinrong Liu,
He Zhou,
Ying Su,
Lin Dong,
Ling Xu,
Haipeng Xu,
Jinghui Lin
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s258896
Subject(s) - erlotinib , wnt signaling pathway , cancer research , lung cancer , cell migration , medicine , cell , cancer , biology , microbiology and biotechnology , signal transduction , pathology , epidermal growth factor receptor , biochemistry
miR-214 has been reported to contribute to erlotinib resistance in non-small-cell lung cancer (NSCLC) through targeting LHX6; however, the molecular mechanisms underlying the involvement of LHX6 in mediating the resistance to EGFR-TKIs in erlotinib-resistant NSCLC HCC827 (HCC827/ER) cells remain unknown. This study aimed to investigate the mechanisms responsible for the contribution of LHX6 to EGFR-TKIs resistance in HCC827/ER cells.