Open Access<p>URM1 Promoted Tumor Growth and Suppressed Apoptosis via the JNK Signaling Pathway in Hepatocellular Carcinoma</p>
Author(s) -
Xin Cheng,
Yu Zhang,
Fei Song,
Fengliang Song,
Cheng Gao,
Xiaoliang Liang,
Feiran Wang,
Zhong Chen
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s258843
Subject(s) - gene knockdown , apoptosis , cancer research , downregulation and upregulation , liver cancer , cell growth , tunel assay , hepatocellular carcinoma , signal transduction , chemistry , medicine , biology , microbiology and biotechnology , biochemistry , gene
Ubiquitin-related modifier 1 (URM1) is a member of the ubiquitin-like regulator family, which acts as a post-translational protein modifier in the oxidative emergency response mechanism. Previous studies have shown that URM1 may be involved in the process of apoptosis and may play a role in JNK signaling pathway. In this study, we aimed to investigate the role and possible mechanism of URM1 in HCC progression.