Open Access<p>FAM46B Promotes Apoptosis and Inhibits Glycolysis of Prostate Cancer Through Inhibition of the MYC-LDHA Axis</p>
Author(s) -
Liang Tao,
Xuxiao Ye,
Dongming Yan,
Chao Deng,
Zuowei Li,
Baohong Tian
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s258724
Subject(s) - prostate cancer , apoptosis , glycolysis , lncap , lactate dehydrogenase a , cancer research , prostate , cancer , biology , medicine , endocrinology , biochemistry , metabolism
Increased dependence on glycolysis is a known element of cancer. This study was designed to examine critical glycolysis components including transcription factor MYC and its downstream target lactate dehydrogenase A (LDHA), potential upstream regulators of glycolysis such as family with sequence similarity 46 member B (FAM46B), and the impact of the abundance of these proteins on apoptosis and glycolysis in prostate cancer.