Open Access<p>Knockdown of miR-183 Enhances the Cisplatin-Induced Apoptosis in Esophageal Cancer Through Increase of FOXO1 Expression</p>
Author(s) -
Hao Chen,
Bin Zheng,
Songtao Xue,
Chun Chen
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s258680
Subject(s) - cisplatin , gene knockdown , apoptosis , esophageal cancer , cancer research , microrna , cancer cell , flow cytometry , cancer , foxo1 , western blot , chemistry , small interfering rna , cell culture , medicine , microbiology and biotechnology , biology , transfection , chemotherapy , biochemistry , gene , protein kinase b , genetics
As an important member of platinum-based chemotherapeutic drugs, cisplatin is effective and is commonly used in the treatment of esophageal cancer. However, repeated use of cisplatin usually causes severe side-effects on patients. Novel approaches should be explored to increase the sensitivity of cancer cells to cisplatin.