Open Access<p>MicroRNA-182 Promotes Cell Migration by Targeting Programmed Cell Death 4 in Hepatocellular Carcinoma Cells</p>
Author(s) -
Junwei Hu,
Zeyu Wang,
Jinjun Wang,
Yicheng Jian,
Junren Dai,
Xiaoping Wang,
Wei Xiong
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s258251
Subject(s) - cancer research , microrna , programmed cell death , cell culture , liver cancer , hepatocellular carcinoma , western blot , cell , cell growth , cancer , luciferase , downregulation and upregulation , reporter gene , cell migration , liver cell , biology , medicine , apoptosis , transfection , gene expression , gene , biochemistry , genetics
Hepatocellular carcinoma (HCC) is the most common primary liver tumor and the third greatest cause of cancer-related death worldwide. Programmed cell death 4 (PDCD4) was reported as a potential tumor-suppressor in hepatocarcinogenesis. However, relatively little is known about mechanisms that regulate PDCD4 expression in HCC. The aim of the present study is to investigate the expression of PDCD4 and miR-182 in human HCC cell lines and clinical HCC specimens and determine whether PDCD4 is a direct target of miR-182 in HCC cell lines.