Open Access<p>Analysis of Key Genes Regulating the Warburg Effect in Patients with Gastrointestinal Cancers and Selective Inhibition of This Metabolic Pathway in Liver Cancer Cells</p>
Author(s) -
Xinyue Zhang,
Jinan Guo,
Parham Jabbarzadeh Kaboli,
Qijie Zhao,
Shixin Xiang,
Jing Shen,
Yueshui Zhao,
Fukuan Du,
Xu Wu,
Mingxing Li,
Huijiao Ji,
Yang Xiao-mi,
Zhangang Xiao,
Qinglian Wen
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s257944
Subject(s) - warburg effect , cancer research , glyceraldehyde 3 phosphate dehydrogenase , cancer , liver cancer , anaerobic glycolysis , cancer cell , glycolysis , biology , metastasis , medicine , gene , gene expression , hepatocellular carcinoma , genetics , metabolism
The Warburg effect, also known as aerobic glycolysis, plays a dominant role in the development of gastrointestinal (GI) cancers. In this study, we analyzed the expression of key genes involved in the Warburg effect in GI cancers and investigated the effect of suppressing the Warburg effect in vitro in liver cancer cell lines.