Open Access<p>Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages</p>
Author(s) -
Si Mi,
Yan Qü,
Xue Chen,
Zhipeng Wen,
Pengxiang Chen,
Yufeng Cheng
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s257852
Subject(s) - ccl5 , cancer research , chemokine , angiogenesis , ccl2 , carcinogenesis , metastasis , tumor microenvironment , western blot , myeloid , downregulation and upregulation , medicine , chemistry , cancer , immunology , inflammation , t cell , immune system , tumor cells , biochemistry , il 2 receptor , gene
Dioxygenase 12-lipoxygenase (12-LOX) plays an important role in tumorigenesis and promotes angiogenesis and proliferation in several tumors, including prostate and breast tumors. Radiotherapy enhances the expression of 12-LOX in esophageal squamous cell carcinoma (ESCC). Two types of macrophages can be found in the tumor microenvironment. The M2 subtype accelerates tumor progression; however, the relationship between 12-LOX and macrophages is not well established. Here, we explore this interaction and its effect on ESCC to induce tumor progression.