Open Access<p>Huaier Restrains Cholangiocarcinoma Progression in vitro and in vivo Through Modulating lncRNA TP73-AS1 and Inducing Oxidative Stress</p>
Author(s) -
Daolin Ji,
Wangyang Zheng,
Peng Huang,
Yongliang Yao,
Xian Zhong,
Pengcheng Kang,
Zhidong Wang,
Guojing Shi,
Yi Xu,
Yunfu Cui
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s257738
Subject(s) - apoptosis , cancer research , metastasis , flow cytometry , in vivo , cell growth , viability assay , oxidative stress , blot , biology , cell migration , cell , cancer , medicine , immunology , biochemistry , genetics , microbiology and biotechnology , gene
Huaier, the fruiting body of Trametes robiniophila Murr, is a kind of traditional Chinese medicine. Recently, many studies have confirmed that Huaier has antitumor effects on various malignancies. Moreover, studies have demonstrated that long noncoding RNAs play an important regulatory role in the occurrence and progression of malignancies. Our present study was to explore whether Huaier has a potential antitumor effect in cholangiocarcinoma and reveal the relationship between lncRNAs and Huaier-induced tumor inhibition.