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Some studies have confirmed tha miRNA-140 exhibits a suppressive role in gastric cancer, Wilms' tumor. However, the function of miRNA-140 in colorectal cancer has not been completely elucidated. The present study aims to verify TRAF6 as the targeted gene by miRNA-140 which was investigated in colorectal cancer tissues and cells, and its effects on the biological characteristics of colorectal cancer cells were determined, in order to provide an experimental and theoretical basis for the application of TRAF6 in the treatment of colorectal cancer.

oncotargets and therapy

&lt;p&gt;The Effects of &lt;em&gt;TRAF6&lt;/em&gt; on Growth and Progression in Colorectal Cancer are Regulated by &lt;em&gt;miRNA-140&lt;/em&gt;&lt;/p&gt;