Open Access<p>The Effects of <em>TRAF6</em> on Growth and Progression in Colorectal Cancer are Regulated by <em>miRNA-140</em></p>
Author(s) -
Guangwei Zhu,
Zhibin Cheng,
Chunlin Lin,
Qin Wang,
Yongjian Huang,
Wei Zheng,
Shugang Yang,
Jianxin Ye
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s257733
Subject(s) - colorectal cancer , microrna , cancer research , western blot , cancer , cell growth , mouse model of colorectal and intestinal cancer , medicine , cancer cell , biology , microbiology and biotechnology , gene , genetics
Some studies have confirmed that miRNA-140 exhibits a suppressive role in gastric cancer, Wilms' tumor. However, the function of miRNA-140 in colorectal cancer has not been completely elucidated. The present study aims to verify TRAF6 as the targeted gene by miRNA-140 which was investigated in colorectal cancer tissues and cells, and its effects on the biological characteristics of colorectal cancer cells were determined, in order to provide an experimental and theoretical basis for the application of TRAF6 in the treatment of colorectal cancer.