Open Access<p>TRPM8 Inhibition Regulates the Proliferation, Migration and ROS Metabolism of Bladder Cancer Cells</p>
Author(s) -
Gang Wang,
Rui Cao,
Kaiyu Qian,
Tianchen Peng,
Lushun Yuan,
Liang Chen,
Songtao Cheng,
Yaoyi Xiong,
Lingao Ju,
Xinghuan Wang,
Yu Xiao
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s257056
Subject(s) - gene knockdown , trpm8 , sod2 , chemistry , cell growth , cancer research , transient receptor potential channel , clonogenic assay , microbiology and biotechnology , cell , biology , apoptosis , superoxide dismutase , biochemistry , receptor , oxidative stress , trpv1
Based on accumulating evidence, transient receptor potential (TRP) ion channels may play important roles in the occurrence and the progression of cancer. TRP melastatin 8 (TRPM8), a member of the TRP family, functions as a Ca 2+ -permeable channel and regulates various physiological and pathological processes. However, the effects of TRPM8 on bladder cancer (BCa) and its underlying mechanisms have not been elucidated.