Open Access<p>Malic Enzyme 1 Indicates Worse Prognosis in Breast Cancer and Promotes Metastasis by Manipulating Reactive Oxygen Species</p>
Author(s) -
Chang Liu,
Ji Cao,
Shuchen Lin,
Yannan Zhao,
Mingyu Zhu,
Zhonghua Tao,
Xichun Hu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s256970
Subject(s) - gene knockdown , breast cancer , metastasis , motility , cancer research , tissue microarray , medicine , cancer , downregulation and upregulation , cell migration , chemistry , biology , cell , apoptosis , microbiology and biotechnology , biochemistry , gene
Malic enzyme 1 (ME1) catalyzes malate to pyruvate and thus promotes glycolysis. Its function in breast cancer remains to be fully clarified. The aim of this work was to investigate the prognostic value of ME1 and its possible mechanism in breast cancer.