Open Access<p>A Six-Epithelial–Mesenchymal Transition Gene Signature May Predict Metastasis of Triple-Negative Breast Cancer</p>
Author(s) -
Li Wei,
Xiao Jun Zhang,
Li Wang,
Li Hu,
Xu Dong Zhang,
Li Li,
Jin Gao
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s256818
Subject(s) - triple negative breast cancer , breast cancer , gene signature , medicine , oncology , metastasis , proportional hazards model , transcriptome , hazard ratio , cancer , cancer research , gene expression profiling , gene expression , gene , biology , genetics , confidence interval
Pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) is associated with favourable outcomes of patients with triple-negative breast cancer (TNBC). However, a proportion of TNBC patients with the residual disease do not relapse and achieve long-term survival. The aim of this study was to identify biomarkers that predict clinical outcomes in these patients.