Open Access<p>NHE1 Mediates 5-Fu Resistance in Gastric Cancer via STAT3 Signaling Pathway</p>
Author(s) -
Zhenni Sun,
Shufang Luan,
Yasai Yao,
Tao Qin,
Xiaomei Xu,
Zan Shen,
Ruyong Yao,
Yue Lu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s256274
Subject(s) - apoptosis , stat3 , cell cycle , transfection , cancer research , microbiology and biotechnology , cancer cell , cell culture , western blot , chemistry , biology , cancer , biochemistry , gene , genetics
Several recent studies have addressed the role of Na+/H+ exchanger isoform 1 (NHE1) in tumor cell growth and apoptosis, including in gastric cancer. However, the role of NHE1 expression related to the 5-Fu resistance in gastric cancer has not been investigated.