Open AccessInteractions Between lncRNA TUG1 and miR-9-5p Modulate the Resistance of Breast Cancer Cells to Doxorubicin by Regulating eIF5A2
Author(s) -
Shuqian Wang,
Mengjing Cheng,
Xiaoxiao Zheng,
Zheng Li,
Hao Liu,
Jianju Lu,
Yu Liu,
Wei Wei Chen
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s255113
Subject(s) - gene knockdown , microrna , cancer research , transfection , downregulation and upregulation , apoptosis , small interfering rna , gene silencing , viability assay , flow cytometry , biology , cell culture , chemistry , microbiology and biotechnology , gene , biochemistry , genetics
Breast cancer (BC) is one of the leading causes of cancer-related deaths. Chemoresistance of BC remains a major unmet clinical obstacle. TUG1 (taurine-upregulated gene 1), a long noncoding RNA (lncRNA), and microRNAs (miRNA) are implicated in therapeutic resistance. However, the interactions between TUG1 and miRNAs that regulate doxorubicin (Dox) resistance in BC remain elusive.