Open Access<p>Elevated Levels of circRUNX1 in Colorectal Cancer Promote Cell Growth and Metastasis via miR-145-5p/IGF1 Signalling</p>
Author(s) -
Zhilei Chen,
Xiangnan Li,
Chun-Xiang Ye,
Hongyu Chen,
Zhenjun Wang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s254133
Subject(s) - gene knockdown , metastasis , colorectal cancer , cancer research , microrna , cell growth , downregulation and upregulation , cancer , biology , pi3k/akt/mtor pathway , cell migration , in vivo , cell , medicine , signal transduction , apoptosis , microbiology and biotechnology , gene , genetics
Emerging evidence suggests that circular RNAs (circRNAs) are vital regulators in a range of cancers. "miRNA sponge" is the most reported role played by circRNAs in many tumors. The insulin-like growth factor (IGF) 1 pathway plays a key role in the development and progression of many cancers, including colorectal cancer (CRC). The aim of the study is to establish the potential clinical value and driving molecular mechanisms of circRNAs in CRC.