Open Access<p>UBE2O Promotes Progression and Epithelial–Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma</p>
Author(s) -
Xiyu Chen,
Shuiting Zhang,
Chao Liu,
Li Guo,
Shanhong Lu,
Yunyun Wang,
Xin Zhang,
Donghai Huang,
Yuanzheng Qiu,
Yong Liu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s253861
Subject(s) - head and neck squamous cell carcinoma , epithelial–mesenchymal transition , cancer research , oncogene , cell growth , tumor progression , angiogenesis , cell , cancer , cell migration , in vivo , biology , pathology , medicine , metastasis , head and neck cancer , cell cycle , genetics , microbiology and biotechnology
UBE2O, as a member of the ubiquitin-conjugating enzyme family, is abnormally expressed and exhibits abnormal functions in human malignancies. However, the function of UBE2O in head and neck squamous cell carcinoma (HNSCC) remains unknown. Therefore, our study aims to investigate the role of UBE2O in HNSCC progression and the underlying mechanisms.