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As the first-line drug for treatment of HER2 -positive metastatic gastric cancer (GC), Herceptin exhibits significant therapeutic efficacy. However, acquired resistance of Herceptin limits the therapeutic benefit of gastric cancer patients, in which the molecular mechanisms remain to be further determined.

<p>ARPP-19 Mediates Herceptin Resistance via Regulation of CD44 in Gastric Cancer</p>