Open Access<p>Effects of Huaier Extract on Ameliorating Colitis-Associated Colorectal Tumorigenesis in Mice</p>
Author(s) -
Yifeng Zou,
Yuming Rong,
Zexian Chen,
Zhihong Shen,
Xi Chen,
Yongtao Tan,
Jing-rong Weng,
Xiaoming Huang,
Xutao Lin
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s253598
Subject(s) - azoxymethane , medicine , apoptosis , colitis , colorectal cancer , carcinogenesis , stat3 , inflammatory bowel disease , western blot , cytokine , cancer , cancer research , gastroenterology , pharmacology , immunology , biology , disease , biochemistry , gene
Huaier extract has been a part of traditional Chinese medicine (TCM) for roughly 1600 years and may serve as a potential anti-cancer drug as it is associated with good efficacy and low toxicity. Individuals with inflammatory bowel disease (IBD) are at a higher chance of being diagnosed with colorectal cancer (CRC) and as Huaier extract may potentially influence tumorigenesis, we set out to determine the effect of Huaier extract on colitis-associated CRC.