Open Access<p>Inhibition of Migration, Invasion and Drug Resistance of Pancreatic Adenocarcinoma Cells – Role of Snail, Slug and Twist and Small Molecule Inhibitors</p>
Author(s) -
Ezgi Kaşıkcı,
Esra Aydemir,
Ömer Faruk Bayrak,
Fikrettin Şahin
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s253418
Subject(s) - gene silencing , slug , cancer research , pancreatic cancer , epithelial–mesenchymal transition , chemistry , cell migration , metastasis , cancer cell , cell , cancer , biology , medicine , biochemistry , gene
The main purpose of this study is to demonstrate the effects of epithelial to mesenchymal transition activating transcription factor silencing (EMT-ATF silencing) on migration, invasion, drug resistance and tumor-forming abilities of various pancreatic cancer cell lines. Additionally, the contribution of small molecule inhibitors of EMT (SD-208 and CX4945) to the effects of gene silencing was evaluated.