Open Access<p>Long Noncoding RNAs in Diffuse Large B-Cell Lymphoma: Current Advances and Perspectives</p>
Author(s) -
Xianbo Huang,
Wenbin Qian,
Xiujin Ye
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s253330
Subject(s) - diffuse large b cell lymphoma , malignancy , lymphoma , pathogenesis , long non coding rna , biology , computational biology , cancer research , bioinformatics , medicine , rna , genetics , gene , immunology
Diffuse large B-cell lymphoma (DLBCL) is a complex and aggressive malignancy originating from B lymphocytes and characterized by extensive clinical, phenotypic and molecular heterogeneity. Although research conducted over the past decades has substantially improved our understanding of DLBCL, its pathogenesis has not yet been fully elucidated. The development of RNA sequencing technology has allowed the identification of numerous long noncoding RNAs (lncRNAs) that exhibit aberrant expression in DLBCL. These lncRNAs play crucial roles in DLBCL development and pathogenesis and are thus good candidates for use as diagnostic biomarkers or therapeutic targets. In this review, we describe the lncRNAs associated with DLBCL, summarize their characteristics and molecular functions, and discuss their relationships with clinical practice.