Open Access<p>SSPH I, a Novel Anti-Cancer Saponin, Inhibits Autophagy and Induces Apoptosis via ROS Accumulation and ERK1/2 Signaling Pathway in Hepatocellular Carcinoma Cells</p>
Author(s) -
Jinling Zhou,
Huang Xiang,
Han-Chen Qiu,
Ri-zhi Gan,
Huan Zhou,
Hongqing Zhu,
Xuanxuan Zhang,
GuoDong Lu,
Gang Li
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s253234
Subject(s) - autophagy , apoptosis , viability assay , chemistry , microbiology and biotechnology , mtt assay , cancer research , mapk/erk pathway , signal transduction , flow cytometry , biology , biochemistry
Saponin of Schizocapsa plantaginea Hance I (SSPH I), a novel bioactive phytochemical isolated from the rhizomes of Schizocapsa plantaginea , has been demonstrated to exhibit anti-cancer activity against various tumors in preclinical studies. However, the molecular mechanisms involved in the suppression of hepatocellular carcinoma (HCC) are poorly understood. The present study aimed at analyzing the effects of SSPH I on autophagy and apoptosis in vitro.